Details
| Name | PS1 |
| Type | somatic mutation |
| Species | Mus musculus |
| Tissue | NA |
| Experiment Method | Western blot |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | These results identify for the first time a transient increase in synaptic function associated with L286V mutated PS1 variant in an age-dependent manner. In addition, they support the view that the PS1 overexpression promotes synaptic dysfunction in an AB |
| Regulation Gene | PS1 |
| Year | 2009 |
| Pubmed ID | 19675248 |
| Title | Age-Dependent Impairment of Spine Morphology and Synaptic Plasticity in Hippocampal CA1 Neurons of a Presenilin 1 Transgenic Mouse Model of Alzheimer's Disease |
| Drug | NA |
| Disease | FAD |
| Environment Factors | NA |
| Circulating | NA |
| Variant | somatic mutation |
| High-throughput | NA |