Details
| Name | PS1M146 |
| Type | somatic mutation |
| Species | Mus musculus |
| Tissue | brain tissue |
| Experiment Method | qPCR |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | In summary, these results demonstrate that the PS1M146L mutation increases mitochondrial ROS formation and oxidative damage in aged mice. Hence, oxidative stress caused by the combined effects of aging and PS1 mutations may be causative for triggering neu |
| Regulation Gene | PS1 |
| Year | 2006 |
| Pubmed ID | 16520237 |
| Title | Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice. |
| Drug | NA |
| Disease | FAD |
| Environment Factors | Oxidation |
| Circulating | NA |
| Variant | somatic mutation |
| High-throughput | NA |