| Name |
R213G
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
C57BL/6, SOD3 Tg, SOD3 lacking HBD Tg, SOD3 Ko, and SOD3R213G Tg mice
|
| Experiment Method |
Immunoblot;Quantitative RT-PCR
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
SOD3(R213G) transgenic mice exhibited premature aging, including hair graying, abnormal gait, and a shortened life span.Specifically, the aged mice showed systemic inflammation and organ degeneration.In addition, aged SOD3(R213G) mice are susceptible to n
|
| Regulation Gene |
SOD3
|
| Year |
2015
|
| Pubmed ID |
25927599
|
| Title |
SOD3 Variant, R213G, Altered SOD3 Function, Leading to ROS-Mediated Inflammation and Damage in Multiple Organs of Premature Aging Mice.
|
| Drug |
null
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|