| Name |
Rac1b
|
| Type |
somatic mutation
|
| Species |
Homo sapiens
|
| Tissue |
HT29 cells, Co115 and Caco-2;The normal colonocyte cell line NCM460
|
| Experiment Method |
SiRNA transfection;Semi-quantitative RT-PCR and Real Time PCR ;SDS-PAGE and Western blotting;Senescence-associated B-galactosidase assay
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
We used normal NCM460 colonocytes as a model to express oncogenic B-Raf-V600E in the presence or absence of co-transfected Rac1b and then analyzed the effect on expression of senescence markers. When oncogenic B-Raf-V600E was expressed we observed the ind
|
| Regulation Gene |
NA
|
| Year |
2015
|
| Pubmed ID |
26341689
|
| Title |
Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells.
|
| Drug |
NA
|
| Disease |
colorectal cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|