| Name |
Ras
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
Mammary tissue
|
| Experiment Method |
qPCR,Western blot
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
In contrast, high levels of Ras activation - similar to those found in tumours bearing endogenous Kras2 mutations - induce cellular senescence that is Ink4a-Arf- dependent and irreversible following Ras downregulation. Chronic low-level Ras induction resu
|
| Regulation Gene |
MMP-3-Stromelysin-1, Plasminogen Activator Inhibitor-1
|
| Year |
2007
|
| Pubmed ID |
17450133
|
| Title |
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
somatic mutation
|
| High-throughput |
NA
|