| Name |
S536D
|
| Type |
somatic mutation
|
| Species |
Homo sapiens
|
| Tissue |
frozen colon cancer and matched normal adjacent tissues;MCF7 and HEK293T cells;DU145 cells and LNCaP, HCT116 and HCT116 p532/2 cells
|
| Experiment Method |
MTT;qRT-PCR;Western blot;Flow cytometry;Immunohistochemistry
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
Phosphomimetic mutation of RelA/p65 at Ser536 induces senescence in HCT116 cells.senescence-associated (SA) bgalactosidase positive cells were up to 48.0 and 77.6% of the detected HCT116 p53 wt and HCT116 p532/2 cells, respectively.In these cells p16 prot
|
| Regulation Gene |
NA
|
| Year |
2016
|
| Pubmed ID |
26375985
|
| Title |
A phosphomimetic mutant of RelA/p65 at Ser536 induces apoptosis and senescence: An implication for tumor-suppressive role of Ser536 phosphorylation.
|
| Drug |
NA
|
| Disease |
colon cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|