A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name circ_Foxo3
Type circRNA
Species Mus musculus
Tissue cardiac
Experiment Method Senescence-associated b-galactosidase staining , western blot and immunohistochemistry,.Real-time PCR
Up/Down Up
Pro/Anti Pro
Funtion Description As a result, ectopic expression of circ-Foxo3 was found to promote cellular senescence (Figure 7D), while silencing circ-Foxo3 decreased cell senescence and apoptosis.
Regulation Gene NA
Year 2017
Pubmed ID 26873092
Title Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses.
Drug doxorubicin
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA