| Name |
SERPINE1
|
| Type |
somatic mutation
|
| Species |
Homo sapiens
|
| Tissue |
pancreas
|
| Experiment Method |
PCR,other
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
a rare loss-of-function mutation in SERPINE1 (c.699_700dupTA), which encodes PAI-1, could play a role in longevity and metabolism in humans.
|
| Regulation Gene |
gene of mRNA of Gadd45a, Cyclin B1, MMP-2, Bcl-2, and Bax
|
| Year |
2018
|
| Pubmed ID |
29152572
|
| Title |
A null mutation in SERPINE1 protects against biological aging in humans.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|