Details
| Name | SMN2 |
| Type | somatic mutation |
| Species | Mus musculus |
| Tissue | cells |
| Experiment Method | RT-qPCR;Western blot |
| Up/Down | Up |
| Pro/Anti | Anti |
| Funtion Description | we identified orally available small molecules that shift the balance of SMN2 splicing toward the production of full-length SMN2 messenger RNA with high selectivity. Administration of these compounds to delta 7 mice, a model of severe SMA, led to an incr |
| Regulation Gene | SMN2 |
| Year | 2014 |
| Pubmed ID | 25104390 |
| Title | Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |