A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name SOD
Type somatic mutation
Species Mus musculus
Tissue mice strains
Experiment Method qPCR
Up/Down Up
Pro/Anti Pro
Funtion Description Expression of high levels of human SOD containing a substitution of glycine to alanine at position 93--a change that has little effect on enzyme activity--caused motor neuron disease in transgenic mice. The mice became paralyzed in one or more limbs as a
Regulation Gene SOD
Year 1994
Pubmed ID 8209258
Title Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant somatic mutation
High-throughput NA