Details
| Name | Spns1 |
| Type | somatic mutation |
| Species | zebrafish |
| Tissue | Zebrafish (AB and casper strains) |
| Experiment Method | Western blotting;PCR;RNA isolation and RT-PCR analysis;Survival and life-span experiments |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | we found that a concurrent disruption of the vacuolar-type H+-ATPase (v-ATPase) subunit gene, atp6v0ca (ATPase, H+ transporting, lysosomal, V0 subunit ca) led to suppression of the senescence induced by the Spns1 defect, whereas the sole loss of Atp6v0ca |
| Regulation Gene | NA |
| Year | 2017 |
| Pubmed ID | 27875093 |
| Title | Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |