Details
| Name | SPOP E3 |
| Type | somatic mutation |
| Species | Homo sapiens |
| Tissue | Prostate tumor specimens |
| Experiment Method | ChIP;immunohistochemistry (IHC) |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | SPOP promotes senescence, an important tumor suppression mechanism, by targeting the SENP7 deSUMOylase for degradation. SPOP is upregulated during senescence. This correlates with ubiquitin-mediated degradation of SENP7, which promotes senescence by incre |
| Regulation Gene | NA |
| Year | 2015 |
| Pubmed ID | 26527005 |
| Title | SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase. |
| Drug | NA |
| Disease | prostate cancer |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |