| Name |
Tmem135
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
FUN025 mice;Primary fibroblasts
|
| Experiment Method |
flow cytometry;Western blotting;Immunocytochemistry;PCR
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
Localization of TMEM135 on mitochondria, and imbalance of mitochondrial fission and fusion in mutant Tmem135 as well as Tmem135 overexpressing cells, indicating that TMEM135 is involved in the regulation of mitochondrial dynamics. Additionally, mutant ret
|
| Regulation Gene |
NA
|
| Year |
2016
|
| Pubmed ID |
27863209
|
| Title |
Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|