| Name |
TRA2B
|
| Type |
somatic mutation
|
| Species |
Homo sapiens
|
| Tissue |
Wild-type and p53/ HCT 116 cells;Human diploid fibroblasts (WI-38 and TIG-3) and SW480 cells
|
| Experiment Method |
Northern blot;Quantitative real-time reverse transcription-PCR;Western blotting;Chromatin immunoprecipitation ;RIP;Fluorescent in situ hybridization
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
The human transformer 2B (TRA2B) gene contains a 419-bp UCR spanning the 276-bp exon 2 and its neighboring introns. TRA2B exon 2 has premature stop codons, whereas an exon 2-containing splice variant (TRA2B4) was expressed preferentially in the nuclei of
|
| Regulation Gene |
CDKN1A, p21,p53
|
| Year |
2016
|
| Pubmed ID |
27043659
|
| Title |
Ultraconserved region-containing Transformer 2B4 controls senescence of colon cancer cells.
|
| Drug |
NA
|
| Disease |
colon cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|