| Name |
TREM-2
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
mice and Neuronal cell lines (SKNF1 and SH-SY5Y)
|
| Experiment Method |
western blotting;RT-PCR;RNA isolation;SDS-PAGE;Immunofluorescence
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
TREM2 not only plays a critical role in inflammation, but is also involved in neuronal cell survival and in neurogenesis.TREM2 is a soluble protein transported by macrophages through ventricle walls and choroid plexus, and then enters the brain parenchyma
|
| Regulation Gene |
NA
|
| Year |
2017
|
| Pubmed ID |
27662313
|
| Title |
Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model.
|
| Drug |
NA
|
| Disease |
neurodegenerative diseases
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|