A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name TSC22D1
Type somatic mutation
Species Homo sapiens
Tissue TGFB (R&D), Tig3(et)-16i and HaCaT cells
Experiment Method qPCR
Up/Down NA
Pro/Anti Pro
Funtion Description Gene-expression profiling revealed a >100-fold increase in the levels of the transcription factor and putative tumour suppressor gene TGFB-stimulated clone 22 (TSC22D1) in BRAF(E600)-induced senescence, in both human fibroblasts and melanocytes. Only the
Regulation Gene TSC22D1
Year 2011
Pubmed ID 21448135
Title Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant somatic mutation
High-throughput NA