| Name |
TSH
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
mice and mice normal thyroids and thyroid tumors
|
| Experiment Method |
immunohistochemical staining;Western blot
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
Induction of senescence by BrafV600E in BVE-PTC transplants via upregulation of Trp53.The p53 expression was associated with strong senescence-associated beta-galactosidase (SA-beta-Gal) activity (strong SA-beta-Gal staining) and the absence of cell proli
|
| Regulation Gene |
p53
|
| Year |
2016
|
| Pubmed ID |
26477313
|
| Title |
TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer.
|
| Drug |
NA
|
| Disease |
papillary thyroid cancers
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|