Details
| Name | V600E |
| Type | somatic mutation |
| Species | Homo sapiens |
| Tissue | cerebral cortex cells |
| Experiment Method | Western Blotting |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | BRAF(V600E) expression initially strongly promoted colony formation but did not lead to significantly increased proliferation. BRAF(V600E)-expressing cells subsequently stopped proliferating and induced markers of oncogene-induced senescence including aci |
| Regulation Gene | BRAF |
| Year | 2011 |
| Pubmed ID | 21636552 |
| Title | BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | somatic mutation |
| High-throughput | NA |