Details
| Name | VEGF receptor 2 |
| Type | somatic mutation |
| Species | Homo sapiens |
| Tissue | U87MG cells;U373MG cells;Immunoblot;Relative Real-time Quantitative PCR;Small Interfering RNA Transfection;ELISA |
| Experiment Method | Immunohistochemistry |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | In human GBM, EGFR overexpression and EGFRvIII positivity were associated with increased VEGFR2 expression. In GBM cells in culture, EGFRvIII-initiated cell signaling increased expression of VEGFR2, which prevented cellular senescence and promoted cell cy |
| Regulation Gene | EGFR |
| Year | 2016 |
| Pubmed ID | 26420897 |
| Title | Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. |
| Drug | cediranib |
| Disease | glioblastoma |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |