Details
| Name | WRN |
| Type | somatic mutation |
| Species | Mus musculus |
| Tissue | Murine embryonic fibroblasts |
| Experiment Method | Western Blotting;qPCR |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | Importantly, WRN(-/-);p53(-/-) mice show an increased mortality rate relative to WRN(+/-);p53(-/-) animals. We consider possible models for the synergy between p53 and WRN mutations for the determination of life span. |
| Regulation Gene | WRN |
| Year | 2000 |
| Pubmed ID | 10757812 |
| Title | Mutations in the WRN gene in mice accelerate mortality in a p53-null background. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |