Details
| Name | XPA |
| Type | somatic mutation |
| Species | Mus musculus |
| Tissue | NA |
| Experiment Method | other |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | TTD mice carrying an additional mutation in XPA, which enhances the DNA repair defect,showed a greatly accelerated aging phenotype, which correlated with an increased cellular sensitivity to oxidative DNA damage. |
| Regulation Gene | XPA |
| Year | 2002 |
| Pubmed ID | 11950998 |
| Title | Premature Aging in Mice Deficient in DNA Repair and Transcription |
| Drug | NA |
| Disease | trichothiodystrophy |
| Environment Factors | NA |
| Circulating | NA |
| Variant | somatic mutation |
| High-throughput | NA |