A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name ZEB1
Type somatic mutation
Species Mus musculus
Tissue NA
Experiment Method qPCR,ChIP
Up/Down Up
Pro/Anti Pro
Funtion Description Mutation of the ZEB1 gene leads to INK4a-independent premature replicative senescence in MEFs.Transfection experiments carried out in HeLa cells by deletion mutants of thePSMD13-SIRT3intergenic region showed a complex pathway of coregulation acting in bot
Regulation Gene ZEB1
Year 2008
Pubmed ID 18192284
Title ZEB1 Links Epithelial-Mesenchymal Transition and Cellular Senescence
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant somatic mutation
High-throughput NA