| Name |
DEC1
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
MCF7, RKO, MCF7-p53-KD,RKO-p53-KD
|
| Experiment Method |
Luciferase Reporter Assay,ChIP,Western Blot
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Moreover, we found that targeting endogenous DEC1 attenuates p53-mediated premature senescence in response to DNA damage. Furthermore, overexpression of DEC1 induces cellular senescence in p53-knockdown cells, albeit to a lesser extent. Finally, we showed
|
| Regulation Gene |
p53
|
| Year |
2007
|
| Pubmed ID |
18025081
|
| Title |
DEC1, a Basic Helix-Loop-Helix Transcription Factor and a Novel Target Gene of the p53 Family, Mediates p53-dependent Premature Senescence
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|