| Name |
delta 40p53
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
Human hepatocellular carcinoma cell lines HuH-1 (TP53WT), HepG2 (TP53WT), Hep3B (TP53/), HuH-7(TP53Y220C), and PLC/PRF/5(TP53R249S)
|
| Experiment Method |
qRT-PCR;Western blot;Clonogenic assay;Cell proliferation assay
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
the percentage of senescence-associated B-galactosidase (SA-B-gal)-positive cells was significantly higher in the TP53+/ delta 40 clones compared to the RI clones. The increase in SA-B-gal-positive cells was continuously observed in the TP53+/ delta 40 cl
|
| Regulation Gene |
NA
|
| Year |
2017
|
| Pubmed ID |
27980070
|
| Title |
delta 40p53a suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells.
|
| Drug |
NA
|
| Disease |
hepatocarcinoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|