| Name |
DAF-2
|
| Type |
gene
|
| Species |
Microbe
|
| Tissue |
Hermaphrodites C. elegans strains wild-type N2, DA1116,CB1372;male flies;Microbe Strain
|
| Experiment Method |
qPCR;RNA Interference;
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
We show that dramatic lifespan extension can be achieved by targeting multiple, evolutionarily conserved aging pathways and mechanisms using drug combinations.We found that drug interactions involved the TGF-B pathway and recruited genes related with IGF
|
| Regulation Gene |
NA
|
| Year |
2018
|
| Pubmed ID |
30269951
|
| Title |
Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling.
|
| Drug |
drug combinations
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|