| Name |
AP4
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
hTERT-RPE cells (or RPE cells), an immortalized human retinal pigment epithelial cell line, and MCF-7, a human breast carcinoma cell line,
|
| Experiment Method |
SDS-PAGE and Western blot;Immunofluorescence staining;SASP;qRT-PCR;ChIP-qPCR
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
when cultured for 24 days, RPE cells with a high level of AP4 exhibit a large, flattened morphology and even cease proliferating; these changes were not observed in DN-AP4-expressing cells or non-induced cells. In addition, AP4-expressing cells exhibited
|
| Regulation Gene |
p53
|
| Year |
2015
|
| Pubmed ID |
26439195
|
| Title |
Ectopic AP4 expression induces cellular senescence via activation of p53 in long-term confluent retinal pigment epithelial cells.
|
| Drug |
NA
|
| Disease |
breast cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|