| Name |
ATF4
|
| Type |
TF
|
| Species |
Mus musculus
|
| Tissue |
primary embryo fibroblasts
|
| Experiment Method |
Luciferase assay,qPCR,Western Blotting
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
Here, we report that ATF4 promotes oncogene-induced neoplastic transformation by suppressing the expression of cellular senescence-associated genes. Strikingly, primary embryo fibroblasts from ATF4-deficient mice were resistant to transformation by coexpr
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
22102693
|
| Title |
Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|