Details
| Name | ATFS-1 |
| Type | TF |
| Species | Caenorhabditis elegans |
| Tissue | NA |
| Experiment Method | RT-PCR |
| Up/Down | Up |
| Pro/Anti | PRO |
| Funtion Description | clk-1, isp-1, and nuo-6 worms all exhibit an ATFS-1-dependent activation of the mitoUPR. While loss of atfs-1 during adulthood does not affect lifespan in any of these strains, absence of atfs-1 during development prevents clk-1 and isp-1 worms from reach |
| Regulation Gene | NA |
| Year | 2018 |
| Pubmed ID | 30563508 |
| Title | Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |