| Name |
Bclaf1
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
Human colon cancer cells HCT116 and human breast adenocarcinoma cells MCF7
|
| Experiment Method |
RT-PCR;ChIP;Immunoprecipitation and western blot;Luciferase assay;Immunofluorescence and immunohistochemistry;Enzyme-linked immunosorbent assay (ELISA);
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Bclaf1 is upregulated through the ATM/Nemo/NF-kB pathway during TIS and is a direct target of p65 and c-Rel. The induction of Bclaf1 by NF-kB is essential for C/EBPB upregulation and IL-6/IL-8 transcription during TIS. Bclaf1 can interact with the leucine
|
| Regulation Gene |
NA
|
| Year |
2016
|
| Pubmed ID |
26794446
|
| Title |
Bclaf1 is an important NF-kB signaling transducer and C/EBPB regulator in DNA damage-induced senescence.
|
| Drug |
doxorubicin
|
| Disease |
xenograft tumor,colon cancer,breast cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|