| Name |
BCL-xL
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
20 centenarians,16 septuagenarians and 14 young people
|
| Experiment Method |
Real-time PCR;Immunofluorescence
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
BcL-xL overexpressing cells exhibited lower accumulation of p16Ink4a, p14Arf, and p21Cip, all of them cell cycle inhibitors and increased proliferation compared to control cells.Moreover, ectopic expression of Bcl-xL significantly delayed the accumulation
|
| Regulation Gene |
NA
|
| Year |
2016
|
| Pubmed ID |
27794564
|
| Title |
Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
1
|
| Variant |
NA
|
| High-throughput |
NA
|