| Name |
c-Maf
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
Adipose tissue from healthy donors
|
| Experiment Method |
Immunophenoyping;RT-PCR;Western blot;RNA silencing;ChIP
|
| Up/Down |
NA
|
| Pro/Anti |
NA
|
| Funtion Description |
We found that vigorous ex vivo expansion of human adipose tissue-derived MSCs (hAMSCs) results in proliferative decline, cell cycle arrest, and altered differentiation capacity.This senescent phenotype was associated with reactive oxygen species (ROS) acc
|
| Regulation Gene |
NA
|
| Year |
2015
|
| Pubmed ID |
26496036
|
| Title |
c-Maf regulates pluripotency genes, proliferation/self-renewal, and lineage commitment in ROS-mediated senescence of human mesenchymal stem cells.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|