A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name Dawdle
Type gene
Species Drosophila melanogaster
Tissue NA
Experiment Method Western blot
Up/Down Down
Pro/Anti Anti
Funtion Description Knockdown of Myo or Daw in adult fruit flies reduced mean lifespan, while overexpression of either ligand in adult muscle tissues but not in adipose tissues enhanced mean lifespan. An examination of ubiquitinated protein aggregates in adult muscles reveal
Regulation Gene NA
Year 2018
Pubmed ID 29615416
Title The Drosophila TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA