| Name |
DAF-16
|
| Type |
TF
|
| Species |
Caenorhabditis elegans
|
| Tissue |
C. elegans strains
|
| Experiment Method |
qPCR
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
Overexpression of DAF-16 in rle-1 mutants increases worm lifespan, while disruption of DAF-16 expression in rle-1 mutants reverses their longevity. Thus, RLE-1 is an E3 ubiquitin ligase of DAF-16 that regulates C. elegans aging.
|
| Regulation Gene |
insulin/IGF-Isignaling pathway
|
| Year |
2007
|
| Pubmed ID |
17276341
|
| Title |
RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
somatic mutation
|
| High-throughput |
NA
|