| Name |
DAF-16/FOXO
|
| Type |
TF
|
| Species |
Caenorhabditis elegans
|
| Tissue |
cells
|
| Experiment Method |
western blot analysis;Quantitative RT-PCR;Chromatin immunoprecipitation
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
DAF-16 directly activates expression of aakg-4, reduction of which suppresses longevity in daf-2 insulin/IGF-1 receptor mutants. This implies that an increase in the activity of AMPK containing the AAKG-4 r subunit caused by direct activation by DAF-16 sl
|
| Regulation Gene |
DAF-16/FoxO
|
| Year |
2014
|
| Pubmed ID |
24516399
|
| Title |
DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|