| Name |
circ_LARP4
|
| Type |
circRNA
|
| Species |
Homo sapiens
|
| Tissue |
liver
|
| Experiment Method |
real-time PCR, SA-B-gal staining,Western blotting,Luciferase reporter assay
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Gain-of-function and loss-of-function assays demonstrated that circLARP4 suppressed HCC cell proliferation, mediated cell cycle arrest and induced senescence in vitro.
|
| Regulation Gene |
miR-761 / RUNX3 / p53 / p21
|
| Year |
2019
|
| Pubmed ID |
30520539
|
| Title |
circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma.
|
| Drug |
NA
|
| Disease |
hepatocarcinoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|