Details
| Name | E2F1 |
| Type | TF |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | RT-PCR |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | We show here that E2F1, a multifunctional transcription factor that binds the retinoblastoma (pRb) tumor suppressor and that can either promote or suppress tumorigenesis, induces a senescent phenotype when overexpressed in normal human fibroblasts. |
| Regulation Gene | E2F1 |
| Year | 2000 |
| Pubmed ID | 10594030 |
| Title | Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |