| Name |
E2F1
|
| Type |
TF
|
| Species |
Mus musculus
|
| Tissue |
murine Embryonic fibroblasts (MEFs)
|
| Experiment Method |
Chromatin Immunoprecipitation Assay;mMnSOD-ChIP-F;Luciferase Reporter Assay;Western blots
|
| Up/Down |
NA
|
| Pro/Anti |
NA
|
| Funtion Description |
E2F1 attenuates FOXO3-mediated expression of MnSOD and Catalase without affecting FOXO3 protein stability, subcellular localization, or phosphorylation by Akt.E2F1 inhibits FOXO3-dependent transcription by directly binding FOXO3 in the nucleus and prevent
|
| Regulation Gene |
NA
|
| Year |
2014
|
| Pubmed ID |
25344604
|
| Title |
E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|