| Name |
FLASH
|
| Type |
TF
|
| Species |
Rat Rattus
|
| Tissue |
Male Wistar rats;A glomerular MC line
|
| Experiment Method |
Immunohistochemistry;Transfection and co-immunoprecipitation;Western blot;RNAi;Quantitative RT-PCR
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
In the absence of BeSO4 stimulation, p21 overexpression showed a significant induction of cellular senescence.Senescent MCs exhibited the characteristic morphology in E12-p21 axis activation, but the morphological changes were suppressed by FLASH express
|
| Regulation Gene |
p21
|
| Year |
2015
|
| Pubmed ID |
26208142
|
| Title |
A Novel Interaction between FLICE-Associated Huge Protein (FLASH) and E2A Regulates Cell Proliferation and Cellular Senescence via Tumor Necrosis Factor (TNF)-Alpha-p21WAF1/CIP1 Axis.
|
| Drug |
NA
|
| Disease |
glomerulonephritis
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|