Details
| Name | FOXO1 |
| Type | TF |
| Species | Homo sapiens |
| Tissue | ES-2 cell line;Ovarian cancer tissues |
| Experiment Method | RT-qPCR;Luciferase and transfection assays;Immunoblotting;ChIP |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | FOXO1 and the PR/FOXO1 target gene p21 (CDKN1A) are repressed by PR-A, but induced by PR-B. In the presence of progestin, PR-B, but not PR-A, robustly induced cellular senescence via FOXO1-dependent induction of p21 and p15 (CDKN2B).Overexpression of cons |
| Regulation Gene | p21,p51 |
| Year | 2016 |
| Pubmed ID | 26577046 |
| Title | Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |