| Name |
FOXP3
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
Human cancer cells (MCF7 and HCT116) and HCT116 p53-null cells;mouse embryonic fibroblasts (MEFs)
|
| Experiment Method |
qRT-PCR;Senescence-associated B-galactosidase analysis;Immunofluorescence;Western blot
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Foxp3 expression resulted in the induction of senescence in epithelial cancer cells, including MCF7 and HCT116 cells. Foxp3 overexpression also increased the intracellular levels of reactive oxygen species (ROS). The ROS inhibitor N-acetyl-l-cysteine resc
|
| Regulation Gene |
p21,p53
|
| Year |
2017
|
| Pubmed ID |
27238838
|
| Title |
Foxp3 is a key downstream regulator of p53-mediated cellular senescence.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|