| Name |
HIF-1
|
| Type |
TF
|
| Species |
Caenorhabditis elegans
|
| Tissue |
Caenorhabditis elegans strains
|
| Experiment Method |
Western blot;Quantitative RT-PCR;RNA interference
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
The worm ortholog of elongin C, elc-1, encodes a subunit of E3 ligase and transcription elongation factor. We found that knockdown of elc-1 prolonged lifespan and delayed paralysis caused by impaired protein homeostasis.We further showed that elc-1 RNA in
|
| Regulation Gene |
HIF-1
|
| Year |
2015
|
| Pubmed ID |
26361075
|
| Title |
Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|