| Name |
HPV16 E2
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
The human cervical cancer cell line SiHa
|
| Experiment Method |
Reporter luciferase;Quantitative real-time PCR;Immunoblotting
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
E2 inhibits endogenous E6 gene expression and sensitizes SiHa cells to TNF-a-induced NF-kB activation.Under this condition there was an increase in the expression of senescent proteins p53, p21, p27 and p16 and senescence-associated (SA)-B-galactosidase a
|
| Regulation Gene |
NA
|
| Year |
2015
|
| Pubmed ID |
25572145
|
| Title |
Re-expression of HPV16 E2 in SiHa (human cervical cancer) cells potentiates NF-kB activation induced by TNF-a concurrently increasing senescence and survival.
|
| Drug |
NA
|
| Disease |
cervical cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|