Details
| Name | HSF1 |
| Type | TF |
| Species | Caenorhabditis elegans |
| Tissue | C. elegans Strains |
| Experiment Method | Western Blotting,qPCR |
| Up/Down | NA |
| Pro/Anti | NA |
| Funtion Description | Here, we report that the activity of HSF-1 is regulated by IIS. This regulation occurs at an early step of HSF-1 activation via two HSF-1 regulators, DDL-1 and DDL-2. Inhibition of DDL-1/2 increases longevity and thermotolerance in an hsf-1-dependent mann |
| Regulation Gene | NA |
| Year | 2012 |
| Pubmed ID | 22265419 |
| Title | HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |