| Name |
HSF1
|
| Type |
TF
|
| Species |
Caenorhabditis elegans
|
| Tissue |
Nematodes and control worms
|
| Experiment Method |
RNAi;Immunofluorescence Staining;FRAP
|
| Up/Down |
NA
|
| Pro/Anti |
NA
|
| Funtion Description |
Heat shock transcription factor 1 (HSF-1) is a main regulator of stress-granule-related RBP aggregation in both young and aged animals. During aging, increasing DAF-16 activity restores dynamic stress-granule-related RBPs, partly by decreasing the buildup
|
| Regulation Gene |
NA
|
| Year |
2017
|
| Pubmed ID |
28076789
|
| Title |
Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|