Details
| Name | IkB kinase B |
| Type | TF |
| Species | Mus musculus |
| Tissue | Mouse fibroblasts |
| Experiment Method | Western blotting;RNA isolation;qRT-PCR;ChIP |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | We show that in vitro ablation of IkkB in fibroblasts led to progressive ROS accumulation and TGFB activation, and ultimately accelerated cell migration, fibroblast-myofibroblast transformation and senescence.Mechanistically, the basal IKKB activity was r |
| Regulation Gene | ROS-TGFB autocrine loop |
| Year | 2016 |
| Pubmed ID | 26946493 |
| Title | Loss of IkB kinase B promotes myofibroblast transformation and senescence through activation of the ROS-TGFB autocrine loop. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |