| Name |
IRF3
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
HeLa, 293T, IMR 90, NIH3T3 cells,U2OS and U2OS-reporter cells,MRC5 cells;Human diploid fibroblast (HDF) cells from patients with Hutchinson-Gilford progeria syndrome (HGPS, cell line AG0989B) and Werner syndrome (WS, cell line AG05229B)
|
| Experiment Method |
qPCR, immunotechniques
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
We found that the transcription factor IRF3, activated in an ATM-IKKa/B-dependent manner, stimulates cell-autonomous IFN-B expression in response to double-stranded DNA breaks. Cells and tissues with accumulating DNA damage produce endogenous IFN-B and st
|
| Regulation Gene |
p53
|
| Year |
2015
|
| Pubmed ID |
25921537
|
| Title |
DNA damage-induced type I interferon promotes senescence and inhibits stem cell function
|
| Drug |
NA
|
| Disease |
Hutchinson-Gilford progeria syndrome,Werner syndrome.
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|