| Name |
JDP2
|
| Type |
TF
|
| Species |
Mus musculus
|
| Tissue |
The JDP2 null mice
|
| Experiment Method |
qPCR;EMSA;Western Blotting;GST Interaction Assay;Immunohistochemistry
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
JDP2 as a novel repressor of GNRH-mediated Fshb induction. JDP2 exhibited high basal expression and bound the Fshb promoter at an AP-1-binding site in a complex with c-JUN. GNRH treatment induced c-FOS to replace JDP2 as a c-JUN binding partner, forming t
|
| Regulation Gene |
NA
|
| Year |
2017
|
| Pubmed ID |
28007961
|
| Title |
c-JUN Dimerization Protein 2 (JDP2) Is a Transcriptional Repressor of Follicle-stimulating Hormone B (FSHB) and Is Required for Preventing Premature Reproductive Senescence in Female Mice*
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|