| Name |
klotho
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
Human aortic smooth muscle cells
|
| Experiment Method |
Immunoblotting;Nrf2 knock-down
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
soluble klotho (1 nM, 24 hrs) significantly induces expression of Nrf2 and the antioxidant enzymes haeme oxygenase (HO-1) and peroxiredoxin-1 (Prx-1) and enhances glutathione levels in human aortic smooth muscle cells (HASMC).Silencing of Nrf2 attenuated
|
| Regulation Gene |
Nrf2
|
| Year |
2017
|
| Pubmed ID |
27696667
|
| Title |
The anti-ageing hormone klotho induces Nrf2-mediated antioxidant defences in human aortic smooth muscle cells.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|