Details
| Name | LRF |
| Type | TF |
| Species | Mus musculus |
| Tissue | embryonic fibroblasts |
| Experiment Method | Western blot |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | LRF-mediated bypass of RAS V12 -induced senescence is accompanied by the induction of several E2F-target genes, including Cyclin E , Cyclin A and p107 . Unexpectedly, LRF exerted this activity independent of several critical senescence inducers, such as p |
| Regulation Gene | Cyclin E,Cyclin A,p107 |
| Year | 2010 |
| Pubmed ID | 19942610 |
| Title | Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | somatic mutation |
| High-throughput | NA |