| Name |
Mfn2
|
| Type |
TF
|
| Species |
Mus musculus
|
| Tissue |
6, 12, and 22 months of age of mouse skeletal muscle
|
| Experiment Method |
Western blotting;real-time PCR;
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
mitofusin 2 (Mfn2) plays a key role in the control of muscle mitochondrial damage. We show that aging is characterized by a progressive reduction in Mfn2 in mouse skeletal muscle and that skeletal muscle Mfn2 ablation in mice generates a gene signature li
|
| Regulation Gene |
HIF1a and BNIP3
|
| Year |
2016
|
| Pubmed ID |
27334614
|
| Title |
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
1
|
| Variant |
NA
|
| High-throughput |
NA
|